کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5522648 1546032 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting sarcoma tumor-initiating cells through differentiation therapy
ترجمه فارسی عنوان
هدف قرار دادن سلول های شروع تومور سارکوم از طریق تمایز درمانی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


- Identification of human sarcomas stem cells by a HLA-I(−) phenotype
- Molecular and functional characterization of HLA-I(−) cells
- Target HLA-I(−) sarcoma stem cells by differentiation therapy

Human leukocyte antigen class I (HLA-I) down-regulation has been reported in many human cancers to be associated with poor clinical outcome. However, its connection to tumor-initiating cells (TICs) remains unknown. In this study, we report that HLA-I is down-regulated in a subpopulation of cells that have high tumor initiating capacity in different types of human sarcomas. Detailed characterization revealed their distinct molecular profiles regarding proliferation, apoptosis and stemness programs. Notably, these TICs can be induced to differentiate along distinct mesenchymal lineages, including the osteogenic pathway. The retinoic acid receptor signaling pathway is overexpressed in HLA-1 negative TICs. All-trans retinoic acid treatment successfully induced osteogenic differentiation of this subpopulation, in vitro and in vivo, resulting in significantly decreased tumor formation. Thus, our findings indicate down-regulated HLA-I is a shared feature of TICs in a variety of human sarcomas, and differentiation therapy strategies may specifically target undifferentiated TICs and inhibit tumor formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stem Cell Research - Volume 21, May 2017, Pages 117-123
نویسندگان
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