کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5524552 | 1546249 | 2016 | 7 صفحه PDF | دانلود رایگان |
- Allogeneic transplant for acute leukemia is associated with favorable survival.
- Nonrelapse mortality is low (6% and 17% and 1 and 3 years, respectively).
- Outcome is determined by leukemia type, disease risk, and donor-recipient sex.
- Donor type (MRD, MUD, haploidentical) has no impact on any transplant outcome.
- Type of donor should not play a major role in the decision to offer transplant.
Allogeneic hematopoietic cell transplantation (alloHCT) is considered the most potent postremission antileukemic therapy in adults with acute leukemia. We analyzed 172 consecutive acute leukemia patients transplanted in complete remission after a T cell-replete alloHCT from either a matched related (MRD, nâ=â54), unrelated (MUD, nâ=â67), or haploidentical (haplo, nâ=â51) donor to look for patient-, disease-, and transplant-related factors associated with post-transplant outcomes. Patients included 123 acute myeloid leukemia patients (first complete remission [CR], n = 94; second CR, n = 28; third CR, n = 1) and 49 acute lymphoblastic leukemia (ALL) patients (first CR, n = 39; second CR, n = 9; third CR, n = 1) with a median age of 50 years (range, 19 to 74). Median follow-up for surviving patients was 38 months. Cumulative incidence of nonrelapse mortality at 1 and 3 years was 6% and 17%, respectively. The estimated rates of 3-year overall survival, disease-free survival, and relapse incidence were 59%, 50%, and 33%, respectively. In multivariate analysis, risk factors for inferior survival included diagnosis of ALL, high risk disease risk index, and use of a female donor for a male recipient. Donor type (MRD, MUD, haplo) had no impact on any transplant outcome. Given the favorable outcomes associated with alloHCT in acute leukemia and lack of effect of donor type, a strong case can be made for transplanting acute leukemia patients in remission as soon as any donor becomes available.
Journal: Biology of Blood and Marrow Transplantation - Volume 22, Issue 10, October 2016, Pages 1816-1822