کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5524806 1546529 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ArticleRisk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics
ترجمه فارسی عنوان
مقاله اصلی در مورد تومورهای سلولی ژرمینه دوران کودکی بدخیم در ارتباط با ویژگی های جمعیت شناسی، بارداری و پری ناتال
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- Pediatric germ cell tumors have unique risk profiles based on histological subtype.
- Yolk sac tumors are more common among children of foreign-born Hispanic mothers.
- Congenital malformations are most likely to co-occur with malignant teratomas.

BackgroundChildhood germ cell tumors (GCTs) are a rare assortment of neoplasms, with mostly unknown etiology, that are believed to originate very early in life. Few studies have examined risk factors by histologic subtype, despite evidence of different risk profiles.Materials and methodsIn this population-based case-control study, 451 childhood malignant GCT cases ages 0-5 years were identified from the California Cancer Registry. Differentiating between common histologic subtypes, we identified 181 yolk sac tumors, 216 teratomas, and 54 rarer subtypes. Cases were linked to their birth certificates and 271,381 controls, frequency matched by birth year, were randomly selected from California birthrolls to investigate the contributions of demographic, gestational, and pregnancy factors using unconditional logistic regression analysis.ResultsCompared to non-Hispanic whites, Asian/Pacific Islander children were at an increased risk for developing GCTs (odds ratio [OR] = 1.94; 95% confidence interval [CI] = 1.47, 2.56). Among pregnancy complications and procedures, yolk sac tumors were positively associated with the presence of fetopelvic disproportion (OR = 2.97; 95% CI = 1.55, 5.68), while teratomas were strongly associated with polyhydramnios or oligohydramnios (OR = 14.76; 95% CI = 7.21, 30.19) and the presence of an ear, face, or neck anomaly at birth (OR = 93.70; 95% CI = 42.14, 208.82).ConclusionsMalignant yolk sac tumors and malignant teratomas exhibited distinct demographic and gestational characteristics; additionally, complications in pregnancy and labor may be brought on by specific histologic subtypes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Epidemiology - Volume 46, February 2017, Pages 42-49
نویسندگان
, , , , ,