کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5527823 1547892 2017 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telomerase and telomere biology in hematological diseases: A new therapeutic target
ترجمه فارسی عنوان
زیست شناسی تلومراز و تلومر در بیماری های هماتولوژیک: یک هدف درمانی جدید
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- Telomeres are structures confined at the ends of eukaryotic chromosomes.
- Telomerase neutralizes loss of telomeric sequences by adding telomere repeats.
- Telomere biology is frequently associated with human cancer.
- Telomerase mutations are risk factors for some hematological diseases.
- There is an increasing interest in targeting telomeres and telomerase in anti-cancer therapy.

Telomeres are structures confined at the ends of eukaryotic chromosomes. With each cell division, telomeric repeats are lost because DNA polymerases are incapable to fully duplicate the very ends of linear chromosomes. Loss of repeats causes cell senescence, and apoptosis. Telomerase neutralizes loss of telomeric sequences by adding telomere repeats at the 3′ telomeric overhang.Telomere biology is frequently associated with human cancer and dysfunctional telomeres have been proved to participate to genetic instability.This review covers the information on telomerase expression and genetic alterations in the most relevant types of hematological diseases.Telomere erosion hampers the capability of hematopoietic stem cells to effectively replicate, clinically resulting in bone marrow failure. Furthermore, telomerase mutations are genetic risk factors for the occurrence of some hematologic cancers. New discoveries in telomere structure and telomerase functions have led to an increasing interest in targeting telomeres and telomerase in anti-cancer therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 56, May 2017, Pages 60-74
نویسندگان
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