کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5535323 1551497 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior
ترجمه فارسی عنوان
قرار گرفتن در معرض آندروژن قبل از زایمان باعث کاهش اندازه تست ها و غلظت اسپرم در گوسفند بدون تغییر تمایز نوروندوکرین و رفتار جنسی مردانه
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


- Excess prenatal androgen reduces testis size, sperm concentration, and breeding potential in rams.
- Prenatal hyperandrogenized rams exhibit male-typical sexual behavior and gonadotropin secretion.
- Mechanisms mediating male reproductive development exhibit resilience to early disruption.

Prenatal androgens are largely responsible for growth and differentiation of the genital tract and testis and for organization of the control mechanisms regulating male reproductive physiology and behavior. The aim of the present study was to evaluate the impact of inappropriate exposure to excess testosterone (T) during the first trimester of fetal development on the reproductive function, sexual behavior, and fertility potential of rams. We found that biweekly maternal T propionate (100 mg) treatment administered from Day 30-58 of gestation significantly decreased (P < 0.05) postpubertal scrotal circumference and sperm concentration. Prenatal T exposure did not alter ejaculate volume, sperm motility and morphology or testis morphology. There was, however, a trend for more T-exposed rams than controls to be classified as unsatisfactory potential breeders during breeding soundness examinations. Postnatal serum T concentrations were not affected by prenatal T exposure, nor was the expression of key testicular genes essential for spermatogenesis and steroidogenesis. Basal serum LH did not differ between treatment groups, nor did pituitary responsiveness to GnRH. T-exposed rams, like control males, exhibited vigorous libido and were sexually attracted to estrous females. In summary, these results suggest that exposure to exogenous T during the first trimester of gestation can negatively impact spermatogenesis and compromise the reproductive fitness of rams.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Domestic Animal Endocrinology - Volume 62, January 2018, Pages 1-9
نویسندگان
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