کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5535353 | 1551500 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Timing and duration of nursing from birth affect neonatal porcine uterine matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1
ترجمه فارسی عنوان
زمان و مدت زمان پرستاری از زمان تولد نوزاد متولد شده به وسیله متالوپروتئیناز 9 ماتریکس رحم و مهار کننده بافت متالوپروتئیناز 1
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کلمات کلیدی
خوک، رحم، نوزادان، لاکتوکریین، ماتریکس متالوپروتئیناز،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Nursing for 2Â d from birth supports neonatal porcine uterine and cervical development. However, it is not clear how timing or duration of lactocrine signaling from birth (postnatal day = PND 0) affects development of neonatal female reproductive tract tissues. Therefore, studies were conducted to determine effects of age at first nursing and duration of nursing from birth on specific elements of the matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) system in uterine and cervical tissues at PND 2. When nursing was initiated at 0Â h or 30Â min of age, targeted proteins, including proMMP9 and MMP9, were detected in uterine and cervical tissues on PND 2, as was uterine TIMP1. However, these proteins were undetectable when nursing was delayed for 12Â h and when gilts were fed milk replacer for 48Â h from birth. Increasing the duration of nursing from 30Â min to 12Â h from birth increased uterine (P < 0.05) and cervical (P < 0.001) MMP9 levels to those observed in gilts nursed for 48Â h. Similarly, uterine TIMP1 levels increased with duration of nursing. Uterine MMP2 levels were detectable but unaffected by age at first nursing or duration of nursing from birth. Uterine MMP2 and MMP9 activities, monitored by zymography, reflected immunoblotting data. Results provide evidence for the utility of MMP9 and TIMP1 as markers of age- and lactocrine-sensitive porcine female reproductive tract development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Domestic Animal Endocrinology - Volume 59, April 2017, Pages 1-10
Journal: Domestic Animal Endocrinology - Volume 59, April 2017, Pages 1-10
نویسندگان
T.Y. Ho, K.M. Rahman, M.E. Camp, A.A. Wiley, F.F. Bartol, C.A. Bagnell,