کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5544673 | 1554994 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phenotypic heterogeneity of peripheral monocytes in healthy dogs
ترجمه فارسی عنوان
ناهمگونی فنوتیپی مونوسیت های محیطی در سگ های سالم
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Monocytes are key cells of the innate immune system. Their phenotypic and functional roles have been investigated in humans, mice and other animals, such as the rat, pig and cow. To date, detailed phenotypic analysis of monocytes has not been undertaken in dogs. Two important surface markers in human monocytes are CD14 and MHC class II (MHC II). By flow cytometry, we demonstrated that canine monocytes can be subdivided into three separate populations: CD14posMHC IIneg, CD14posMHC IIpos and CD14negMHC IIpos. Both light and transmission electron microscopy confirmed the monocytic identity of all three populations. The CD14posMHC IIneg population could be distinguished on an ultrastructural level by their smaller size, the presence of more numerous, larger granules, and more pseudopodia than both of the other populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 190, August 2017, Pages 26-30
Journal: Veterinary Immunology and Immunopathology - Volume 190, August 2017, Pages 26-30
نویسندگان
Natalie Gibbons, Michelle R. Goulart, Yu-Mei Chang, Konstantinos Efstathiou, Robert Purcell, Ying Wu, Laureen M. Peters, Mark Turmaine, Balazs Szladovits, Oliver A. Garden,