کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5589182 | 1569808 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic polymorphisms in CYP2A6 are associated with a risk of cigarette smoking and predispose to smoking at younger ages
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کلمات کلیدی
MAFCYP2A6cpd - CPDnicotine addiction - اعتیاد به نیکوتینcigarettes per day - سیگار در روزHeavy smokers - سیگاری های سنگینLight smokers - سیگاری های نورNicotine metabolism - متابولیسم نیکوتینMexican Mestizo - متیسو مکزیکیNever-smokers - هرگز سیگاریSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nicotine is the main component of cigarettes that causes addiction, which is considered a complex disease, and genetic factors have been proposed to be involved in the development of addiction. The CYP2A6 gene encodes the main enzyme responsible for nicotine metabolism. Depending on the study population, different genetic variants of CYP2A6 associated with cigarette smoking have been described. Therefore, we evaluated the possible association between SNPs in CYP2A6 with cigarette smoking and nicotine addiction-related variables in Mexican mestizo smokers. We performed a genetic association study comparing light smokers (LS, n = 349), heavy smokers (HS, n = 351) and never-smokers (NS, n = 394). SNPs rs1137115, rs4105144, rs1801272 and rs28399433 were genotyped in the CYP2A6 gene. We found that the A allele of rs1137115 (OR = 1.41) in exon 1 of CYP2A6 and the T allele of rs4105144 (OR = 1.32) in the 5ⲠUTR of the gene are associated with the risk of cigarette smoking (p < 0.05); rs1137115 affects the level of alternative splicing, resulting in a CYP2A6 isoform with low enzymatic activity, whereas rs4105144 is likely to be in a binding site for the transcription factor for glucocorticoids receptor (GR) and regulates the expression of CYP2A6. In addition, having a greater number of risk alleles (rs1137115 (A), rs4105144 (T) and rs28399433 (G)) is associated with a younger age at onset. The present study shows that in Mexican mestizos, the analyzed SNPs confer greater risk in terms of consumption and age of onset.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 628, 10 September 2017, Pages 205-210
Journal: Gene - Volume 628, 10 September 2017, Pages 205-210
نویسندگان
Gloria Pérez-Rubio, Luis Alberto López-Flores, Alejandra RamÃrez-Venegas, Valeri Noé-DÃaz, Leonor GarcÃa-Gómez, Enrique Ambrocio-Ortiz, Candelaria Sánchez-Romero, Rafael De Jesús Hernández-Zenteno, Raúl Humberto Sansores,