کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5589387 | 1569799 | 2017 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AGXT2 rs37369 polymorphism predicts the renal function in patients with chronic heart failure
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کلمات کلیدی
ADMAWRFChFsDMAAGXT2worsening renal function - تشدید عملکرد کلیهBUN - خوبsymmetric dimethylarginine - دی متیل آرژینین متقارنasymmetric dimethylarginine - دی متیل آرژینین نامتقارنRenal function - عملکرد کلیهChronic heart failure - نارسایی مزمن قلبیblood urea nitrogen - نیتروژن اوره خونPolymorphism - پلی مورفیسم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Patients with chronic heart failure (CHF) are often accompanied with varying degrees of renal diseases. The purpose of this study was to identify rs37369 polymorphism of AGXT2 specific to the renal function of CHF patients. A total of 1012 southern Chinese participants, including 487 CHF patients without history of renal diseases and 525 healthy volunteers, were recruited for this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the genotypes of AGXT2 rs37369 polymorphism. Levels of blood urea nitrogen (BUN) and serum creatinine (SCr) were detected to indicate the renal function of the participants. BUN level was significantly higher in CHF patients without history of renal diseases compared with healthy volunteers (p = 0.000). And the similar result was also obtained for SCr (p = 0.000). Besides, our results indicated that the level of BUN correlated significantly with SCr in both the CHF patients without renal diseases (r = 0.4533, p < 0.0001) and volunteers (r = 0.2489, p < 0.0001). Furthermore, we found that the AGXT2 rs37369 polymorphism could significantly affect the level of BUN in CHF patients without history of renal diseases (p = 0.036, AA + AG vs GG). Patients with rs37369 GG genotype showed a significantly reduced level of BUN compared to those with the AA genotype (p = 0.024), and the significant difference was still observed in the smokers of CHF patients without renal diseases (p = 0.023). In conclusion, we found that CHF might induce the impairment of kidney and cause deterioration of renal function. AGXT2 rs37369 polymorphism might affect the renal function of CHF patients free from renal diseases, especially in patients with cigarette smoking.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 637, 30 December 2017, Pages 145-151
Journal: Gene - Volume 637, 30 December 2017, Pages 145-151
نویسندگان
Xiao-Lei Hu, Wen-Jing Zeng, Mu-Peng Li, Yong-Long Yang, Da-Bin Kuang, He Li, Yan-Jiao Zhang, Chun Jiang, Li-Ming Peng, Hong Qi, Ke Zhang, Xiao-Ping Chen,