کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5594113 1571288 2017 42 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intra-individual variability in cerebrovascular and respiratory chemosensitivity: Can we characterize a chemoreflex “reactivity profile”?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Intra-individual variability in cerebrovascular and respiratory chemosensitivity: Can we characterize a chemoreflex “reactivity profile”?
چکیده انگلیسی
Intra-individual variability in the magnitude of human cerebrovascular and respiratory chemoreflex responses is largely unexplored. By comparing response magnitudes of cerebrovascular CO2 reactivity (CVR; middle and posterior cerebral arteries; MCA, PCA), central (CCR; CO2) and peripheral respiratory chemoreflexes (PCR; CO2 and O2), we tested the hypothesis that a within-individual reactivity magnitude profile could be characterized. The magnitudes of CVR and CCR were tested with hyperoxic rebreathing and PCR magnitudes were tested through transient respiratory tests (TT-CO2, hypercapnia; TT-N2, hypoxia). No significant intra-individual relationships were found between CCR vs. CVR (MCA and PCA), CCR vs. PCR (TT-N2 or TT-CO2) (r < 0.2, P > 0.3) response magnitudes. Statistically significant relationships were found between MCA vs. PCA reactivity (r = 0.45, P < 0.01) and PCR TT-N2 vs. PCR TT-CO2 (r = 0.79, P < 0.001) responses. Using qualitative and quantitative comparisons, we conclude that an intra-individual chemoreflex reactivity magnitude profile cannot be characterized. These data highlight the considerable between- and within-individual variability that exists in human cerebrovascular and respiratory chemoreflexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 242, August 2017, Pages 30-39
نویسندگان
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