Using artificial diets to understand the nutritional physiology of Drosophila melanogaster

Artificial diets have been in use for rearing insects for more than 100 years. Their composition ranges from completely chemically defined (holidic), to semi-defined (meridic) to non-defined (oligidic). Recently, meridic and holidic diets have been used to demonstrate previously unrecognised nutrient-sensitive behaviours and patterns of fitness trait expression in adult Drosophila melanogaster. This article presents a summary of the basic nutritional requirements of Drosophila followed by an account of some of these nutrient-modified phenotypes and what they can reveal about fundamental mechanisms. Precisely controlled nutrition, combined with the many advantages of Drosophila present an ideal system for the development of large scale metabolic modelling.