کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5764118 | 1625913 | 2017 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tris(1,3-dichloro-2-propyl) phosphate disrupts axonal growth, cholinergic system and motor behavior in early life zebrafish
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کلمات کلیدی
Ngn1MC-LRTris(1,3-dichloro-2-propyl) phosphateMBPTDCIPPGAPDHDE-71SYN2Gap43CPFBDE-47PBDEsBPAACh - آهAChE - آهیAcetylcholine - استیل کولینAcetylcholinesterase - استیل کولین استرازBisphenol A - بیسفنول ای، بیسفنول ATransgenic - تراریختهDechlorane Plus - دکلوران پلاسPolybrominated diphenyl ethers - دیفنیل اتر پلی بوروندیAxonal growth - رشد Axonalgrowth associated protein 43 - رشد پروتئینی مرتبط با آن 43Motor behavior - رفتار موتورCholinergic system - سیستم CholinergicZebrafish larvae - لاروهای Zebrafishmicrocystin-LR - میکروسیستین LRNeurogenin 1 - نوروژنین 1Myelin basic protein - پروتئین پایه میلینChlorpyrifos - کلرپیریفوسglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tris(1,3-dichloro-2-propyl) phosphate disrupts axonal growth, cholinergic system and motor behavior in early life zebrafish Tris(1,3-dichloro-2-propyl) phosphate disrupts axonal growth, cholinergic system and motor behavior in early life zebrafish](/preview/png/5764118.png)
چکیده انگلیسی
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) could have neurotoxic effects and alter motor behaviors in zebrafish (Danio rerio) larvae, however, the underlying mechanisms are still unknown. In this study, zebrafish embryos were subjected to waterborne exposure of TDCIPP at 100, 300, 600, 900 μg/L from 2 to 120-h post-fertilization (hpf). Behavioral measurements indicate that TDCIPP exposure significantly elevated spontaneous movement, and altered swimming behavior response of larvae to both light and dark stimulation. Interestingly, in accordance with these motor effects, TDCIPP significantly decreased expression of the neuron-specific GFP in transgenic (HuC-GFP) zebrafish larvae as well as decreased expression of the neural marker genes elavl3 and ngn1, inhibited the axonal growth of the secondary motoneurons and altered the expressions of axon-related genes (α1-tubulin, shha and netrin2) in zebrafish larvae. Furthermore, TDCIPP exposure at 900 μg/L significantly increased the activity of acetylcholinesterase (AChE) enzyme, and decreased the total acetylcholine (ACh) concentration. Our data indicate that the alteration in motor neuron and inhibition of cholinergic system could together lead to the TDCIPP induced motor behavior alterations in zebrafish larvae.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 192, November 2017, Pages 7-15
Journal: Aquatic Toxicology - Volume 192, November 2017, Pages 7-15
نویسندگان
Rui Cheng, Yali Jia, Lili Dai, Chunsheng Liu, Jianghua Wang, Guangyu Li, Liqin Yu,