کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5790810 | 1553989 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of polymorphisms of beta-2-microglobulin gene (β2m) with milk IgG1 content in Chinese Holstein dairy cows
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Beta-2-microglobulin (β2m) is an integral component of the Fc receptor (FcRn) heterodimer which is involved in IgG transfer across mammary epithelial cells. The aim of this study was to estimate the frequency of alleles of β2m and the association of SNPs genotypes as well as haplotypes with milk IgG1 concentration and mass. Blood DNA from 189 Chinese Holstein dairy cows was extracted, sequenced and genotyping was analyzed. Milk IgG1 concentrations from these cows were determined by ELISA and evaluated with respect to their β2m genotypes. The results showed that two single nucleotide polymorphisms (SNPs) and one insertion/deletion (indel) of two base pairs, assorted into four haplotypes, were identified. The genotypes and haplotypes of β2m were found to be correlated (P < 0.05) with milk IgG1 concentration and mass. Dairy cows with homozygous deletion of β2m had the lowest milk IgG1 concentration and mass. These results indicate that β2m genotypes could serve as a marker to identify dairy cows with high IgG1 milk levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Livestock Science - Volume 143, Issues 2â3, February 2012, Pages 289-292
Journal: Livestock Science - Volume 143, Issues 2â3, February 2012, Pages 289-292
نویسندگان
Shengguo Zhao, Guanglei Liu, Jiaqi Wang, Chunlin Zhang, Dengpan Bu, Kailang Liu, Lingyun Zhou,