کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5796941 1555056 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identifying innate immune pathways of the chicken may lead to new antiviral therapies
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Identifying innate immune pathways of the chicken may lead to new antiviral therapies
چکیده انگلیسی

Zoonotic viruses, such as highly pathogenic avian influenza (HPAI), present a significant threat to both the poultry industry and public health. The present method of controlling avian influenza (AI) relies on good farming practice with limited use of vaccination in some countries. However, new ways to control disease outbreaks might be possible with additional knowledge of the natural host response to virus. Moreover, manipulation of the innate immune system in mammals improves the outcomes following viral infection. A similar approach might be applied to the chicken, nevertheless, a greater knowledge of the chicken innate immune system is required. This review outlines important mammalian antiviral mechanisms that have been modulated to strengthen viral immunity and highlights the potential application of these strategies in the chicken, especially in regards, to AI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 148, Issues 1–2, 15 July 2012, Pages 100-109
نویسندگان
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