کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5797038 1555090 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages
چکیده انگلیسی

Autophagy is a major intracellular pathway for the lysosomal degradation of long-lived cytoplasmic macromolecules and damaged or surplus organelles. More recently, autophagy has also been linked with innate and adaptive immune responses against intracellular pathogens, including Mycobacterium tuberculosis, which can survive within macrophages by blocking fusion of the phagosome with lysosomes. Induction of autophagy by the Th1 cytokine IFN-γ enables infected macrophages to overcome this phagosome maturation block and inhibit the intracellular survival of mycobacteria. Conversely, the Th2 cytokines IL-4 and IL-13 inhibit autophagy in murine and human macrophages. We discuss how differential modulation of autophagy by Th1 and Th2 cytokines may represent an important feature of the host response to mycobacteria.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 128, Issues 1–3, 15 March 2009, Pages 37-43
نویسندگان
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