کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5797470 1111753 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanomedicine in veterinary oncology
ترجمه فارسی عنوان
نانومواد در انکولوژی دامپزشکی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


- Nanomedicine is an interdisciplinary field that combines medicine, engineering, chemistry, biology and material sciences.
- Nanoparticle-based agents are currently under intensive investigation for cancer treatment in humans and animals.
- Nanoparticle-based agents can overcome several limitations associated with conventional oncology protocols.
- Nanoparticles can be applied for cancer diagnosis and imaging.

Nanomedicine is an interdisciplinary field that combines medicine, engineering, chemistry, biology and material sciences to improve disease management and can be especially valuable in oncology. Nanoparticle-based agents that possess functions such as tumor targeting, imaging and therapy are currently under intensive investigation. This review introduces the basic concept of nanomedicine and the classification of nanoparticles. Because of their favorable pharmacokinetics, tumor targeting properties, and resulting superior efficacy and toxicity profiles, nanoparticle-based agents can overcome several limitations associated with conventional diagnostic and therapeutic protocols in veterinary oncology.The two most important tumor targeting mechanisms (passive and active tumor targeting) and their dominating factors (i.e. shape, charge, size and nanoparticle surface display) are discussed. The review summarizes published clinical and preclinical studies that utilize different nanoformulations in veterinary oncology, as well as the application of nanoparticles for cancer diagnosis and imaging. The toxicology of various nanoformulations is also considered. Given the benefits of nanoformulations demonstrated in human medicine, nanoformulated drugs are likely to gain more traction in veterinary oncology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 205, Issue 2, August 2015, Pages 189-197
نویسندگان
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