کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5797498 | 1111753 | 2015 | 4 صفحه PDF | دانلود رایگان |
- Rapidly proliferating cells have higher levels of activity of thymidine kinase (TK).
- TK activity in serum is a potential biomarker for the presence of neoplasia.
- Serum TK activity in horses with lymphoma was significantly higher than in healthy horses or horses with other tumours.
- Serum TK activity is a potentially useful biomarker for equine lymphoma.
Serum thymidine kinase (sTK) activity is a tumour marker used as a prognostic indicator for lymphoma in humans, dogs and cats. The aim of this study was to evaluate the clinical utility of sTK as a biomarker for lymphoma in horses. Serum samples were collected from clinically normal horses (nâ=â37), horses with lymphoma (nâ=â23), horses with non-haematopoietic neoplasia (nâ=â9) and horses with inflammatory disease (nâ=â14). sTK was measured using a radioenzyme assay. A reference cut-off value ofâ<2.7âU/L (meanâ+â2 standard deviations, SDs) was established using data from clinically normal horses. sTK activity (meanâ±âSD) was 26.3â±â91.5âU/L (range 0.8-443âU/L) for horses with lymphoma, 2.3â±â1.4âU/L (range 0.6-5.7âU/L) for horses with non-haematopoietic neoplasia and 1.5â±â0.6âU/L (range 0.6-2.8âU/L) for horses with inflammatory disease. Horses with lymphoma had significantly higher sTK activity than horses without clinical signs of disease (Pâ<0.01), horses with inflammatory disease (Pâ<0.01) and horses with non-haematopoietic neoplasia (Pâ<0.05). sTK activity is a potentially useful biomarker for equine lymphoma.
Journal: The Veterinary Journal - Volume 205, Issue 2, August 2015, Pages 313-316