کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5797702 | 1111758 | 2015 | 6 صفحه PDF | دانلود رایگان |
- Metamizole is equivalent to carprofen in dogs for extended postoperative analgesia.
- A new formulation of metamizole causes vomiting in dogs.
- Metamizole is an effective hyperalgesic in dogs undergoing ovariohysterectomy.
A newly developed slow-release tablet formulation of metamizole was compared with carprofen for post-operative analgesia in dogs undergoing ovariohysterectomy. Twenty-three dogs were randomly assigned to one of two groups, and administered 50âmg/kg metamizole PO (Group M) or 4âmg/kg carprofen PO (Group C) 1âh before anaesthetic induction and 24 and 48âh later. Anaesthesia was induced with propofol and maintained with isoflurane and fentanyl, after premedication with 0.005âmg/kg medetomidine and 0.3âmg/kg methadone IM. A blinded observer assessed post-operative sedation, and analgesia using a visual analogue scale, a dynamic interactive visual analogue scale, the Glasgow composite pain scale (GCPS), and a mechanical nociceptive threshold device (Tâ=â0.5, 1, 2, 4, 8, 12, 18, 21, 24, 36, 45, 60 and 70âh after surgery). Rescue methadone was administered if the GCPS was >6/24 in ambulatory dogs, or >5/20 in non-ambulatory dogs. Plasma concentrations of test drugs were quantified.The dose range for metamizole was 39-56âmg/kg. At Tâ=â0.5âh sedation scores were significantly higher in Group C and GCPS scores were significantly higher in Group M. Three dogs required rescue methadone (Group M, nâ=â1; Group C, nâ=â2). Vomiting occurred post-operatively in 45% of dogs in Group M. Carprofen and metamizole were both well absorbed; peak concentrations occurred within 4-24âh, and 4-16âh for carprofen and metamizole, respectively. Both drugs provided adequate analgesia of similar duration. No side effects were observed with carprofen while vomiting was frequent following administration of metamizole.
Journal: The Veterinary Journal - Volume 204, Issue 1, April 2015, Pages 99-104