کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5798897 | 1111783 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Overexpression of histidine-rich calcium binding protein in equine ventricular myocardium Overexpression of histidine-rich calcium binding protein in equine ventricular myocardium](/preview/png/5798897.png)
Histidine-rich calcium binding protein (HRC) is a high capacity, low affinity Ca2+ binding protein, specifically expressed in striated muscles of mammals. In rabbit skeletal and cardiac muscles, HRC binds to sarcoplasmic reticulum (SR) membranes via triadin, a junctional SR protein. Recently, a potential role in heart failure and arrhythmogenesis has been assigned to HRC due to its activity as regulator of SR Ca2+ uptake and Ca2+ release. HRC might play a particularly relevant role in the equine heart, given its slower resting heart rate (20-35Â beats/min) and longer action potential duration (APD) (0.6-1.0Â s) than are found in other mammals.The results from this study showed for the first time direct evidence that HRC protein in equine cardiac muscle was expressed in association with the SR membranes and that HRC transcriptional activity was three times higher in the ventricles compared to the atria. The predominance of HRC mRNA up-regulation in ventricular myocardium was specific to the horse heart, since a more even distribution between atria and ventricles was found in animals of similar body size or species, such as cattle or domestic donkeys.
Journal: The Veterinary Journal - Volume 193, Issue 1, July 2012, Pages 157-161