کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5894811 1154444 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Placental deposition of C-reactive protein is a common feature of human pregnancy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Placental deposition of C-reactive protein is a common feature of human pregnancy
چکیده انگلیسی


- We investigated CRP immunoreactivity in human placentas.
- CRP positivity is lower in preeclampsia with FGR than in sPTD or preeclampsia.
- CRP immunopositivity is positively associated with acute chorioamnionitis.
- CRP immunopositivity is inversely associated with maternal vascular underperfusion.
- Placental CRP immunoreactivity mirrors maternal serum CRP concentration.

This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 36, Issue 6, June 2015, Pages 704-707
نویسندگان
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