Trans-placental passage and anti-inflammatory effects of solithromycin in the human placenta

Solithromycin is the first antibiotic of its class to exhibit efficient maternal-to-fetal transfer across the human placenta and is thus an ideal candidate for evaluation for the treatment of intrauterine and fetal infections in pregnancy. At pharmacological concentrations it does not appear to inhibit pro-inflammatory cytokine production by placental cells.