کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5895847 1154486 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationHydrogen sulfide producing enzymes in pregnancy and preeclampsia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Short communicationHydrogen sulfide producing enzymes in pregnancy and preeclampsia
چکیده انگلیسی

Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H2S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H2S-production and may aid in the anti-angiogenic state.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 33, Issue 6, June 2012, Pages 518-521
نویسندگان
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