IGF-I and IGFBP-3 in healthy 9Â month old infants from the SKOT cohort: Breastfeeding, diet, and later obesity

Breastfeeding has a strong negative effect on IGF-I concentrations in late infancy. Although IGF-I concentrations at 9 months of age were negatively associated with change in BMI during the following 9 months we speculate that this could reflect an early adiposity rebound and thereby an increased risk of obesity later in life.