کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5907207 1160003 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A beta-defensin 1-like antimicrobial peptide from the tree shrew, Tupaia belangeri
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
A beta-defensin 1-like antimicrobial peptide from the tree shrew, Tupaia belangeri
چکیده انگلیسی

A novel beta-defensin 1-like antimicrobial peptide (β-defensin 1TB) containing 36 amino acid residues was purified and characterized from the serum of the tree shrew, Tupaia belangeri. Its amino acid sequence was determined as DHYLCVKNEGICLYSSCPSYTKIEGTCYGGKAKCCK, by Edman degradation, mass spectrometry analysis, and cDNA cloning. Evolution analysis indicated that β-defensin 1TB showed maximal similarity to the β-defensin 1 identified from cotton-top tamarin, Saguinus oedipus. β-defensin 1TB exerted potential antimicrobial activities against wide spectrum of microorganisms including Gram-negative and -positive bacteria and fungi. It showed little hemolitic activity to human or rabbit red cells. To the best of our knowledge, this is the first report of antimicrobial peptide from Tupaiidae.

► A novel β-defensin 1-like peptide was purified from the tree shrew, Tupaia belangeri. ► The first report of antimicrobial peptide from the family Tupaiidae. ► The current work provided further support that tree shrews are close to primates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 509, Issue 2, 10 November 2012, Pages 258-262
نویسندگان
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