Novel dual-binding function of a poly (C)-binding protein 3, transcriptional factor which binds the double-strand and single-stranded DNA sequence

► PCBP3 is capable of binding to both double and single strand poly(C) sequences. ► PCBP3 repressed the expression of luciferase with single- and double- strand constructs. ► PCBP3 is a repressor dependent on binding to single and double stranded poly(C).