LADA and T1D in Estonian population - Two different genetic risk profiles

► Best-fitted genetic risk model of T1D contains HLA, INS, PHTF1, CTLA4, CD226, NAA25. ► Best-fitted genetic risk model of LADA contains only protective HLA-DQB1 and CTLA4. ► HLA and some non-HLA loci describe quite well genetic risk for T1D but not for LADA. ► LADA and T1D have two different genetic risk profiles. ► The genetic background for LADA may be lower than expected for T1D.