|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|59148||1419420||2016||9 صفحه PDF||سفارش دهید||دانلود رایگان|
This report describes a new three-component strategy for the regioselective synthesis of a series of tri-substituted pyridazines via a 1,4-diazabicyclo[2, 2 and 2]octane (DABCO)-catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one-pot route toward a diverse set of 3,6-diaryl-4-methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base-organocatalyst, and affords good to excellent yields of products.
Graphical AbstractThis work describes the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines directly from a DABCO-catalyzed three-component condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water.Figure optionsDownload as PowerPoint slide
Journal: Chinese Journal of Catalysis - Volume 37, Issue 4, April 2016, Pages 517–525