Time-of-day specific changes in metabolic detoxification and insecticide resistance in the malaria mosquito Anopheles gambiae

- Previous work identified rhythmically expressed metabolic detoxification enzymes.
- Here we show that these rhythms are conserved in a second mosquito strain, Mali-NIH.
- There are temporal changes in GST activity in body and head extracts.
- Mosquitoes exhibited a diel rhythm in survivorship to DDT exposure.
- Mosquitoes exhibited a bimodal variation to deltamethrin challenge.