کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5925845 | 1571296 | 2016 | 10 صفحه PDF | دانلود رایگان |
- Current tracheal surgical guidelines found to neglect important geometric measures.
- Constriction, curvature, glottal alignment and deviation all found to play a role.
- Subjects' work of breathing affected by these measures.
- Utilised area metric introduced to characterise tracheal flow and power loss.
This paper considers factors that play a significant role in determining inspiratory pressure and energy losses in the human trachea. Previous characterisations of pathological geometry changes have focussed on relating airway constriction and subsequent pressure loss, however many pathologies that affect the trachea cause deviation, increased curvature, constriction or a combination of these. This study investigates the effects of these measures on tracheal flow mechanics, using the compressive goitre (a thyroid gland enlargement) as an example.Computational fluid dynamics simulations were performed in airways affected by goitres (with differing geometric consequences) and a normal geometry for comparison. Realistic airways, derived from medical images, were used because idealised geometries often oversimplify the complex anatomy of the larynx and its effects on the flow. Two mechanisms, distinct from stenosis, were found to strongly affect airflow energy dissipation in the pathological tracheas. The jet emanating from the glottis displayed different impingement and breakdown patterns in pathological geometries and increased loss was associated with curvature.
Journal: Respiratory Physiology & Neurobiology - Volume 234, December 2016, Pages 69-78