کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5925885 | 1571323 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Derivation of recruitment function from the pressure-volume curve in an acute lung injury model
ترجمه فارسی عنوان
تشخیص تابع استخدام از منحنی حجم فشار در یک مدل آسیب حاد ریه
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
چکیده انگلیسی
Lung volume changes involve the recruitment of collapsed alveoli and the expansion of already opened alveoli. This study aimed to determine the alveolar recruitment function by using a mathematical model from a pressure-volume curve (P-V curve). We assumed a lung model as VLÂ =Â R(P)Â V0f(P), where R recruitment function is the fraction of recruited alveoli, V0 is the resting lung volume at FRC of a fully recruited lung, and f(P) corresponds to the normalized compliance function of the lungs open to ventilation. Seven white rabbits were subjected to saline-lavage lung injury, and P-V curves were calculated using the slow inflation technique. We obtained the P-R curve from the P-V curve, and two curves were differently shaped after lung injury. We concluded that the recruitment function was obtained from the P-V curve and that the P-R curve estimated the recruitment and derecruitment status.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 205, 1 January 2015, Pages 16-20
Journal: Respiratory Physiology & Neurobiology - Volume 205, 1 January 2015, Pages 16-20
نویسندگان
Yoshihiro Uzawa, Mikiya Otsuji, Koichi Nakazawa, Wei Fan, Yoshitsugu Yamada,