کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5926003 1167332 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Central and peripheral factors contributing to obstructive sleep apneas
ترجمه فارسی عنوان
عوامل مرکزی و محیطی که باعث آپنه انسدادی خواب می شوند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی


- We review the central and peripheral contributions to obstructive sleep apnea.
- We examine the dynamic interactions between central pre-motor elements and motor output that give rise to obstructive sleep apnea.
- We discuss the complex interplay between both peripheral and central components that cause apneas.

Apnea, the cessation of breathing, is a common physiological and pathophysiological phenomenon. Among the different forms of apnea, obstructive sleep apnea (OSA) is clinically the most prominent manifestation. OSA is characterized by repetitive airway occlusions that are typically associated with peripheral airway obstructions. However, it would be an oversimplification to conclude that OSA is caused by peripheral obstructions. OSA is the result of a dynamic interplay between chemo- and mechanosensory reflexes, neuromodulation, behavioral state and the differential activation of the central respiratory network and its motor outputs. This interplay has numerous neuronal and cardiovascular consequences that are initially adaptive but in the long-term become major contributors to morbidity and mortality. Not only OSA, but also central apneas (CA) have multiple, and partly overlapping mechanisms. In OSA and CA the underlying mechanisms are neither “exclusively peripheral” nor “exclusively central” in origin. This review discusses the complex interplay of peripheral and central nervous components that characterizes the cessation of breathing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 189, Issue 2, 1 November 2013, Pages 344-353
نویسندگان
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