کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5926023 | 1167332 | 2013 | 8 صفحه PDF | دانلود رایگان |
- Motor units display diverse contractile and fatigue properties.
- Muscle fiber atrophy and weakness may disproportionately affect specific fiber types.
- Various diseases result in selective atrophy of muscle fibers in the most fatigable motor units.
- Impact of muscle fiber atrophy on motor performance depends on affected motor unit types.
In skeletal muscles, motor units comprise a motoneuron and the group of muscle fibers innervated by it, which are usually classified based on myosin heavy chain isoform expression. Motor units displaying diverse contractile and fatigue properties are important in determining the range of motor behaviors that can be accomplished by a muscle. Muscle fiber atrophy and weakness may disproportionately affect specific fiber types across a variety of diseases or clinical conditions, thus impacting neuromotor control. In this regard, fiber atrophy that affects a specific fiber type will alter the relative contribution of different motor units to overall muscle structure and function. For example, in various diseases there is fairly selective atrophy of type IIx and/or IIb fibers comprising the strongest yet most fatigable motor units. As a result, there is muscle weakness (i.e., reductions in force per cross-sectional area) associated with an apparent improvement in resistance to fatiguing contractions. This review will examine neuromotor control of respiratory muscles such as the diaphragm muscle and the impact of muscle fiber atrophy on motor performance.
Journal: Respiratory Physiology & Neurobiology - Volume 189, Issue 2, 1 November 2013, Pages 411-418