کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5926063 | 1167334 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of Bacillus Calmette-Guérin Moreau vaccine on lung remodeling in experimental asthma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impact of Bacillus Calmette-Guérin Moreau vaccine on lung remodeling in experimental asthma Impact of Bacillus Calmette-Guérin Moreau vaccine on lung remodeling in experimental asthma](/preview/png/5926063.png)
چکیده انگلیسی
We analyzed the effects of different administration routes and application times of the BCG-Moreau strain on airway and lung inflammation and remodeling in a murine model of allergic asthma. BALB/c mice (n = 168) were divided into two groups. The first group received BCG-Moreau strain while the second group received saline using the same protocol. BCG or saline were intradermally or intranasally injected one or two months before the induction of asthma. Mice were further sensitized and challenged with ovalbumin or received saline. Twenty-four hours after the last challenge, BCG prevented the triggering of pro-inflammatory cytokines, probably by increasing Foxp3 and interleukin (IL)-10, modulating eosinophil infiltration and collagen fiber deposition, thus reducing airway hyperresponsiveness. In conclusion, BCG-Moreau prevented lung remodeling in the present model of allergic asthma, regardless of administration route and time of vaccination. These beneficial effects may be related to the increase in regulatory T cells and to IL-10 production in tandem with decreased Th2 cytokines (IL-4, IL-5, and IL-13).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 189, Issue 3, 1 December 2013, Pages 614-623
Journal: Respiratory Physiology & Neurobiology - Volume 189, Issue 3, 1 December 2013, Pages 614-623
نویسندگان
Cynthia dos Santos Samary, Mariana Alves Antunes, Johnatas Dutra Silva, Adriana Lopes da Silva, Carla Cristina de Araújo, Ilka Bakker-Abreu, Bruno Lourenço Diaz, Sandra Fernezlian, Edwin Roger Parra, Vera Luiza Capelozzi, Pedro Leme Silva,