کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5926127 | 1167338 | 2013 | 9 صفحه PDF | دانلود رایگان |
- The haematological responses to initial acclimation (IA) and of re-acclimation (RA) to hypoxia were studied in mice.
- The serum [EPO] response was blunted in all RA groups compared to IA but the resulting reticulocyte response was similar in all experimental groups.
- Erythropoietic regulation is altered during RA in a manner that is dependent on the paradigm of initial exposure.
Haematological responses throughout 4Â w of initial acclimation (IA) and three paradigms of re-acclimation (RA) to hypoxia (FIO2=0.12) were examined in female mice. We hypothesised that (i) haematological responses would be increased during re-exposure, resulting in greater O2-carrying capacity in RA compared to IA; and (ii) further improvements would occur when abbreviating the de-acclimation period to 1Â w (RAâDA) or extending the IA period to 8Â w (RAâIA). The serum [EPO] response was blunted in all RA groups compared to IA but the resulting reticulocyte response was similar in all experimental groups. The [Hb] response was the same in RA and RAâDA as in IA but was blunted in RAâIA due to a reduction in mean corpuscular Hb. The sensitivity of EPO-producing cells appears blunted but the sensitivity of erythroid precursors to EPO is enhanced by recent hypoxic exposure. Erythropoietic regulation is altered during RA in a manner that is dependent on the paradigm of initial exposure.
Journal: Respiratory Physiology & Neurobiology - Volume 189, Issue 1, 1 October 2013, Pages 153-161