Frontiers reviewFast oscillations during gasping and other non-eupneic respiratory behaviors: Clues to central pattern generation

- Distinct generators or network reorganization may underlie different breathing modes.
- Fast oscillations (HFO and MFO) are present in respiratory-related nerve spectra.
- Synchronous motoneuronal discharge plausibly underlies fast oscillations.
- Fast oscillation dynamics differ in eupnea versus non-eupneic respiratory behaviors.
- HFO dynamics during non-eupneic respiration informs central pattern generation.

The mammalian nervous system exhibits fast synchronous oscillations, which are especially prominent in respiratory-related nerve discharges. In the phrenic nerve, they include high- (HFO), medium- (MFO), and low-frequency (LFO) oscillations. Because motoneurons firing at HFO-related frequencies had never been recorded, an epiphenomenological mechanism for their existence had been posited. We have recently recorded phrenic motoneurons firing at HFO-related frequencies in unanesthetized decerebrate rats and showed that they exhibit dynamic coherence with the phrenic nerve, validating synchronous motoneuronal discharge as a mechanism underlying the generation of HFO. In so doing, we have helped validate the conclusions of previous studies by us and other investigators who have used changes in fast respiratory oscillations to make inferences about central respiratory pattern generation. Here, we seek to review changes occurring in fast synchronous oscillations during non-eupneic respiratory behaviors, with special emphasis on gasping, and the inferences that can be drawn from these dynamics regarding respiratory pattern formation.