Respiratory signaling of locus coeruleus neurons during hypercapnic acidosis in the bullfrog, Lithobates catesbeianus

► Neurons located within the locus coeruleus of the bullfrog brainstem are exquisitely sensitive to physiological changes in pH. ► Some individual neurons of the locus coeruleus are intrinsically chemosensitive. ► Membrane resistance of intrinsically chemosensitive neurons in the locus coeruleus increase during hypercapnic acidosis.