3,5,4′-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1α

► 3,5,4′-Tri-O-acetylresveratrol alleviated histological changes in lung. ► 3,5,4′-Tri-O-acetylresveratrol reversed changes injury mediators. ► 3,5,4′-Tri-O-acetylresveratrol inhibited expression of NF-κB and HIF-1α. ► NF-κB and HIF-1α expression in A549 cells challenged by seawater. ► Correlation analysis between transcription factors and downstream mediators.