Effects of intra-abdominal pressure on respiratory system mechanics in mechanically ventilated rats

► We model intra-abdominal hypertension by helium pneumoperitoneum in rats. ► Intra-abdominal pressure reduces respiratory system compliance. ► PEEP counterbalances increased intra-abdominal pressure during mechanical ventilation. ► The analysis of intratidal compliance could be helpful for guiding the PEEP.