کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5926369 | 1571340 | 2012 | 10 صفحه PDF | دانلود رایگان |
Baroreflex sensitivity (BRS) is reduced in humans during snoring, however the mechanisms are unknown. We used an anaesthetised rabbit induced snoring (IS) model, to test: (1) whether IS was associated with reduced BRS; and (2) if snoring related vibration transmission to peri-carotid tissues influenced BRS levels. BRS was quantified using the spontaneous sequence technique. During IS, BRS fell by 40%, without any associated change in blood pressure (BP) but accompanied by an increase in heart rate (HR). Direct application of a snore frequency and intensity matched vibratory stimulus to the peri-carotid tissues of non-snoring tracheostomised rabbits had no effect on BRS, HR or BP. In conclusion, IS induced depression of BRS is likely mediated via a HR driven change in BRS operating point that is unrelated to snoring-related vibration transmission to carotid baroreceptors. The anaesthetised IS rabbit provides a model in which mechanistic interactions between snoring and BRS can be further explored.
⺠BRS depression during snoring is likely mediated via heart rate driven change in baroreflex operating point. ⺠Snoring-related vibration transmission to the peri-carotid tissue is not associated with the snoring related reduction in BRS. ⺠The anaesthetised IS rabbit provides a model in which mechanistic interactions between snoring and BRS can be further explored.
Journal: Respiratory Physiology & Neurobiology - Volume 180, Issues 2â3, 15 March 2012, Pages 342-351