کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5926431 | 1571341 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A 'Good' muscle in a 'Bad' environment: The importance of airway smooth muscle force adaptation to airway hyperresponsiveness A 'Good' muscle in a 'Bad' environment: The importance of airway smooth muscle force adaptation to airway hyperresponsiveness](/preview/png/5926431.png)
Asthma is characterized by airway inflammation, with a consequent increase in spasmogens, and exaggerated airway narrowing in response to stimuli, termed airway hyperresponsiveness (AHR). The nature of any relationship between inflammation and AHR is less clear. Recent ex vivo data has suggested a novel mechanism by which inflammation may lead to AHR, in which increased basal ASM-tone, due to the presence of spasmogens in the airways, may “strengthen” the ASM and ultimately lead to exaggerated airway narrowing. This phenomenon was termed “force adaptation” [Bossé, Y., Chin, L.Y., Paré, P.D., Seow, C.Y., 2009. Adaptation of airway smooth muscle to basal tone: relevance to airway hyperresponsiveness. Am. J. Respir. Cell Mol. Biol. 40, 13-18]. However, it is unknown whether the magnitude of the effect of force adaptation ex vivo could contribute to exaggerated airway narrowing in vivo. Our aim was to utilize a computational model of ASM shortening in order to quantify the potential effect of force adaptation on airway narrowing when all other mechanical factors were kept constant. The shortening in the model is dictated by a balance between physiological loads and ASM force-generating capacity at different lengths. The results suggest that the magnitude of the effect of force adaptation on ASM shortening would lead to substantially more airway narrowing during bronchial challenge at any given airway generation. We speculate that the increased basal ASM-tone in asthma, due to the presence of inflammation-derived spasmogens, produces an increase in the force-generating capacity of ASM, predisposing to AHR during subsequent challenge.
⺠The force-generating capacity of the airway smooth muscle is plastic (adaptable). ⺠Increasing tone increases airway smooth muscle force-generating capacity. ⺠Gain in force may significantly increases airway resistance to airflow.
Journal: Respiratory Physiology & Neurobiology - Volume 179, Issues 2â3, 15 December 2011, Pages 269-275