کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5926511 1167362 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of micro-embolism size on haemodynamic changes in the pulmonary micro-circulation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
The impact of micro-embolism size on haemodynamic changes in the pulmonary micro-circulation
چکیده انگلیسی

Embolus occlusion of pulmonary arteries can result in elevated pulmonary blood pressures, often resulting in pulmonary hypertension (PH). Experimental observations have shown that small emboli (diameter <170 μm) can have a disproportionate effect on pulmonary vascular resistance (PVR) compared with larger emboli for the same tissue occlusion. We present an anatomically based theoretical model of perfusion in the acinar blood vessels designed to investigate changes in PVR following occlusion of arteries <500 μm in diameter. The model predicts that emboli lodged near proximal capillary beds have a greater effect on PVR - regardless of their size - than emboli occluding 200 μm diameter arterioles, with PH occurring for 10% less tissue occlusion. Capillary blood pressures are predicted to exceed 24 mmHg (levels initiating capillary wall damage) in regions of the capillary bed at approximately the onset of PH. This study focuses on the effect of mechanical obstruction alone; however, we present simple models of vasoconstriction illustrating an increased impact on PVR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 175, Issue 3, 15 March 2011, Pages 365-374
نویسندگان
, , ,