کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5926527 | 1167364 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma](/preview/png/5926527.png)
چکیده انگلیسی
The impact of obesity on the inflammatory process has been described in asthma, however little is known about the influence of diet-induced obesity on lung remodeling. For this purpose, 56 recently weaned A/J mice were randomly divided into 2 groups. In the C group, mice were fed a standard chow diet, while OB animals received isocaloric high-fat diet to reach 1.5 of the mean body weight of C. After 12 weeks, each group was further randomized to be sensitized and challenged with ovalbumin (OVA) or saline. Twenty-four hours after the last challenge, collagen fiber content in airways and lung parenchyma, the volume proportion of smooth muscle-specific actin in alveolar ducts and terminal bronchiole, and the number of eosinophils in bronchoalveolar lavage fluid were higher in OB-OVA than C-OVA. In conclusion, diet-induced obesity enhanced lung remodeling resulting in higher airway responsiveness in the present experimental chronic allergic asthma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 177, Issue 2, 31 July 2011, Pages 141-148
Journal: Respiratory Physiology & Neurobiology - Volume 177, Issue 2, 31 July 2011, Pages 141-148
نویسندگان
Simone A. Saraiva, Adriana L. Silva, Débora G. Xisto, Soraia C. Abreu, Johnatas D. Silva, Pedro L. Silva, Tatiana P.F. Teixeira, Edwin R. Parra, Ana Laura N. Carvalho, Raquel Annoni, Thais Mauad, Vera L. Capelozzi, Patricia M.R. Silva, Marco A. Martins,