کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5926628 | 1167385 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Excitatory and inhibitory effects of opioid agonists on respiratory motor output produced by isolated brainstems from adult turtles (Trachemys)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Excitatory and inhibitory effects of opioid agonists on respiratory motor output produced by isolated brainstems from adult turtles (Trachemys) Excitatory and inhibitory effects of opioid agonists on respiratory motor output produced by isolated brainstems from adult turtles (Trachemys)](/preview/png/5926628.png)
چکیده انگلیسی
To determine how central opioid receptor activation alters turtle breathing, respiratory-related hypoglossal (XII) motor bursts were recorded from isolated adult turtle brainstems during 60 min bath applications of agonists for delta- (DOR), kappa- (KOR), or nociceptin/orphanin (NOR) receptors. DADLE (DOR agonist) abolished XII burst frequency at 0.3-0.5 μM. DPDPE (DOR agonist) increased frequency by 40-44% at 0.01-0.1 μM and decreased frequency by 88 ± 8% at 1.0 μM. U-50488 and U-59693 (KOR agonists) decreased frequency by 65-68% at 100 and 50 μM, respectively. Orphanin (NOR agonist) decreased frequency by 31-51% at 1.0-2.0 μM during the first 30 min period. Orphanin (0.5 and 2.0 μM) increased bursts/episode. Although morphine (10 μM) abolished frequency in nearly all brainstems, subsequent co-application of phenylephrine (α1-adrenergic agonist, 20-100 μM) with morphine restored activity to 16-78% of baseline frequency. Thus, DOR, KOR, and NOR activation regulates frequency and NOR activation regulates episodicity, while α1-adrenergic receptor activation reverses opioid-induced respiratory depression in turtles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 170, Issue 1, 31 January 2010, Pages 5-15
Journal: Respiratory Physiology & Neurobiology - Volume 170, Issue 1, 31 January 2010, Pages 5-15
نویسندگان
Stephen M. Johnson, Christina M. Moris, Michelle E. Bartman, Liana M. Wiegel,