کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
606503 1454532 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular uptake and transcytosis of lipid-based nanoparticles across the intestinal barrier: Relevance for oral drug delivery
ترجمه فارسی عنوان
جذب سلولی و ترانس سیتوزیس نانوذرات مبتنی بر لیپیدها در برابر مانع روده: اهمیت تحویل داروهای خوراکی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی

Oral administration is the preferred route for drug delivery and nanosystems represent a promising tool for protection and transport of hardly soluble, chemically unstable and poorly permeable drugs through the intestinal barrier.In the present work, we have studied lipid nanoparticles cellular uptake, internalization pathways and transcytosis routes through Caco-2 cell monolayers.Both lipid nanosystems presented similar size (∼180 nm) and surface charge (−30 mV). Nanostructured lipid carriers showed a higher cellular uptake and permeability across the barrier, but solid lipid nanoparticles could enter cells faster than the former. The internalization of lipid nanoparticles occurs mainly through a clathrin-mediated endocytosis mechanism, although caveolae-mediated endocytosis is also involved in the uptake.Both lipid nanoparticles were able to cross the intestinal barrier by a preferential transcellular route. This work contributed to a better knowledge of the developed nanosystems for the oral delivery of a wide spectrum of drugs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 463, 1 February 2016, Pages 258–265
نویسندگان
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