کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
607301 1454575 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Infrared, Raman and NMR investigations of risedronate adsorption on nanocrystalline apatites
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Infrared, Raman and NMR investigations of risedronate adsorption on nanocrystalline apatites
چکیده انگلیسی


• Interaction of risedronate/nanocrystalline apatite was studied.
• A global approach was adopted using complementary techniques (FTIR, RAMAN, NMR).
• Calcium risedronate salt was synthesised and fully characterised for comparison.
• Risedronate adsorption on apatite corresponds to an ion substitution reaction.

The aim of the current work was to study the physico-chemical interactions of a bisphosphonate molecule, risedronate, with a well-characterised synthetic nanocrystalline apatite (NCA) as a model bone mineral. We adopted a global approach, using complementary physico-chemical techniques such as FTIR, RAMAN and NMR spectroscopies in order to learn more about the interaction process of risedronate with the apatitic surface. The results obtained suggest that risedronate adsorption corresponds to an ion substitution reaction with phosphate ions occurring at the crystal surface. This mechanism explains the greater amount adsorbed (N) for NCA, compared to well crystallised stoichiometric hydroxyapatite, attributable to the well-developed hydrated layer at the surface of the nanocrystals. However, most calcium ions remain attached to the solid phase and the formation of insoluble risedronate calcium salts must also be considered as a competitive reaction to the adsorption. Thus a calcium risedronate salt was synthesised and fully characterised for comparison to the solids after adsorption. Following spectroscopic results, it can be concluded that a strong interaction was established between risedronate ions and calcium ions at the apatitic surface. However, under these experimental conditions there is no nucleation of a distinct calcium risedronate salt and the apatite crystals retain their integrity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 420, 15 April 2014, Pages 101–111
نویسندگان
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