کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
607779 1454601 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New insights on the mechanisms of drug release from highly concentrated emulsions
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
New insights on the mechanisms of drug release from highly concentrated emulsions
چکیده انگلیسی

High kinetic stability water-in-oil high internal phase ratio emulsions (W/O-HIPREs) have been obtained in a 0.5% Theophylline (TP) aqueous solution/Cremophor WO7/liquid paraffin system at 25 °C. The release of TP has been studied from HIPREs with pH values of the dispersed phase ranging between 2 and 12. Although the release from aqueous solutions was not influenced by pH, the release from HIPREs depended strongly on the pH of the dispersed phase. Increasing the solubility of TP in the dispersed phase, its apparent diffusion coefficient decreased over two orders of magnitude. Two different physico-chemical models have been applied to describe the diffusion of TP, showing an excellent agreement with experiments and confirming the role of the structure of the emulsions and the solubility of the drug. It has been shown that only non-ionized species are able to cross the interfacial film. Therefore, at pH > pKa diffusion is limited by the concentration of non-ionized species inside the emulsion droplets, while at pH < pKa diffusion is determined by the interfacial film. This demonstrates that solubility of the diffusing molecule can have a higher effect on release from HIPREs than the interfacial film properties.

Figure optionsDownload high-quality image (151 K)Download as PowerPoint slideHighlights
► Stable W/O-HIPREs obtained with pH values of the dispersed phase from 2 to 12.
► The release of TP from HIPREs is slow, incomplete after 24h and dependent on pH.
► By increasing drug solubility in HIPREs, the interfacial effect on release vanishes.
► TP diffusion drops sharply when increasing solubility in the dispersed phase.
► The role of HIPRE structure and drug solubility in the release is confirmed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 394, 15 March 2013, Pages 337–345
نویسندگان
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