Synthesis of gold nanoparticles in niosomes

This work outlines a novel method for the synthesis of stable gold nanoparticles within the spatially confined region of vesicles. For the first time, Span/cholesterol based niosomes have been used for nanoparticle synthesis. The restricted geometry within niosomes prevents nanoparticle aggregation. The results have important implications for controlled delivery of nanoparticles for therapeutic applications.

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► Gold nanoparticles were synthesized in Span-based niosomes.
► Stable, crystalline GNPs have been produced by this method.
► The niosomal cavity provides good control over nanoparticle size and shape.
► β-cyclodextrin extracts out cholesterol from the niosomal bilayer.