Electrically induced lipid migration in non-lamellar phase

Inverted hexagonal blocks of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) lipid adsorbed on a polyethyleneimine (PEI)-coated surface in deionized water transformed its shape upon the application of an electric field, forming lipid objects in a variety of shapes (e.g. lines with a width of 10–50 μm). The phenomenon was driven by the electrophoresis, because the zwitterionic lipid, DOPE turned out to be highly negatively charged in deionized water. The interaction between DOPE and the PEI surface stabilized the system, assuring a lifetime over several weeks for the formed structures after the electric field was switched off. The free-drawing of microscopic objects (lines, crosses, and jelly fish) was also achieved by controlling the direction of the lipid movement with the field direction.

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► We report the electrically induced migration of DOPE lipids.
► The electrophoresis is the dominant cause for the phenomenon.
► The lifetime of the formed lipid objects is a few weeks.
► The direction of the lipid movement is controlled by the electric field direction.
► The free-drawing of microscopic objects was demonstrated in several shapes.