کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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608297 | 880576 | 2012 | 7 صفحه PDF | دانلود رایگان |
An evaluation of the physical interactions between gemini surfactants, DNA, and 1,2-dialkyl-sn-glycero-3-phosphoethanolamine helper lipid is presented in this work. Complexation between gemini surfactants and DNA was first investigated using surface tensiometry where the surface tension profiles obtained were found to be consistent with those typically observed for mixed surfactant–polymer systems; that is, there is a synergistic lowering of the surface tension, followed by a first (CAC) and second (CMC) break point in the plot. The surfactant alkyl tail length was observed to exhibit a significant effect on the CAC, thus demonstrating the importance of hydrophobic interactions during complexation between gemini surfactants and DNA. The second study presented is an investigation of the mixing interactions between gemini surfactants and DOPE using Clint’s, Rubingh’s, and Motomura’s theories for mixed micellar formation. The mixing interactions between the 16–3–16/16–7–16/16–12–16/16–7NH–16 gemini surfactants and DOPE were observed to be antagonistic, where the strength of antagonism was found to be dependent upon the gemini surfactant spacer group and the solution composition.
Figure optionsDownload high-quality image (67 K)Download as PowerPoint slideHighlights
► Gemini surfactant/DNA/lipid systems have been studied by surface tension.
► DNA/gemini surfactant interactions depend strongly on hydrophobic interactions.
► Antagonistic mixing is observed for gemini surfactant/lipid systems.
Journal: Journal of Colloid and Interface Science - Volume 377, Issue 1, 1 July 2012, Pages 237–243