کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
609460 880624 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cholesterol induced CTAB micelle-to-vesicle phase transitions
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Cholesterol induced CTAB micelle-to-vesicle phase transitions
چکیده انگلیسی

Vesicles prepared by self-assembly of a hydrated mixture of a cationic surfactant (cetyltrimethylammonium bromide) and a lipid (cholesterol) are studied as potential nanocarriers for the delivery of active ingredients. The understanding of the mechanism of the micelle-to-vesicle transition involved in the vesicle formation appears to be crucial regarding the stability of the vesicles as nanovectors. Here, UV–Vis spectroscopy is used to monitor the phase transition from micelles to vesicles promoted by the progressive addition of cholesterol to CTAB micellar solutions. The employed solvatochromic indicator, pinacyanol chloride (PIN), is a cyanine dye that is highly sensitive to the polarity of the medium. The self-assembly between the CTAB and the cholesterol molecules is investigated by means of turbidity (optical density) measurements as well.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 350, Issue 1, 1 October 2010, Pages 10–15
نویسندگان
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